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3. Indirect effects. Mitotic death and apoptosis
We can help you reset your password using the email address linked to your BioOne Complete account. Relat. Find support for a specific problem on the support section of our website. The experimental survival data used to benchmark the extensions of our model were taken from Hirayama et al. However, the contribution did not reach zero even at very high LETs and was estimated to be 32% at an LET of 2106 keV/μm. Direct and Indirect Ionizing Radiation Photons and particles with sufficient energy have the ability to liberate orbital electrons from atoms and their corresponding molecules. The biological effects of radiation originate principally in damages to DNA. The effect of different concentrations of dimethyl sulfoxide (DMSO), an effective radical scavenger, has been simulated at different dose levels in normoxic and hypoxic conditions for various cell lines. Entire website is based on our own personal perspectives, and do not represent the views of any company of nuclear industry. Contact
Translations are not retained in our system. The demand for personalized medicine in radiotherapy has been met by a surge of mechanistic models offering predictions of the biological effect of ionizing radiation under consideration of a growing number of parameters. Neither BioOne nor the owners and publishers of the content make, and they explicitly disclaim, any express or implied representations or warranties of any kind, including, without limitation, representations and warranties as to the functionality of the translation feature or the accuracy or completeness of the translations. Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, GermanyDivision of Molecular and Translational Radiation Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital, 69120 Heidelberg, GermanyHeidelberg Institute of Radiation Oncology (HIRO), German Cancer Research Center (DKFZ), 69120 Heidelberg, GermanyGerman Cancer Consortium (DKTK), 69120 Heidelberg, GermanyHeidelberg Ion-Beam Therapy Center (HIT), 69120 Heidelberg, GermanyFaculty of Physics and Astronomy, Heidelberg University, 69120 Heidelberg, GermanyAuthor to whom correspondence should be addressed. An institutional or society member subscription is required to view non-Open Access content.
OSTI.GOV Journal Article: THE INDIRECT ACTION OF X AND ULTRAVIOLET RADIATION. B. You currently do not have any folders to save your paper to! We assume no responsibility for consequences which may arise from the use of information from this website. Ionizing radiation may break the bonds that hold the water molecule together, producing radicals such as hydroxyl OH, superoxide anion O 2 – and others. and A.M.; formal analysis, H.L., I.D. Main purpose of this project is to help the public learn some interesting and important information about the peaceful uses of nuclear energy. those of the individual authors and contributors and not of the publisher and the editor(s). DNA damages by X rays as well as heavy ions are induced by a combination of direct and indirect actions. The contribution of indirect action to cell killing decreased with increasing LET. You are surrounded by ionizing radiation. This results in the production of free radicals, which are The number of free radicals produced by ionizing radiation depends on the total dose. Please let us know what you think of our products and services. Help us to further improve by taking part in this short 5 minute survey That is why cancer therapy uses radiation to kill cancer cells. THE INDIRECT ACTION OF X AND ULTRAVIOLET RADIATION (in French) Full Record; Other Related Research; Authors: Bacq, Z.M.
There are two mechanisms by which radiation ultimately affects cells.
[Various experimental investigations have implied, that both for cell survival [Throughout the calculations, the lethality parameters Conceptualization, A.M.; methodology, H.L., A.M. and I.D. If the absorption of radiation occurs in the molecule in which the lesion appears, then this is the direct action of radiation,while with indirect action the absorption of the radiation energy and the response to this energy occur in different molecules. In particular, dimethyl sulfoxide (DMSO) is an effective scavenger of the OH radical, one of the main mediators of low linear energy transfer (LET) radiation induced cellular damage, and has been widely used to investigate the indirect action of ionizing radiation [12,16,17,18].
Create a new folder below. Therefore, even though the radiochemically estimated
The contribution of indirect action in cell killing can be estimated from the maximum degree of protection by dimethylsulfoxide (DMSO), which suppresses indirect action without affecting direct action. Mos otf the experiments reported in th literature oen th inactivatioe ofn viruses by radiation hav no employete d highly purified virus preparations, and thus even when they Ultimately, this adds to the existing versatility of UNIVERSE to consider multiple radio-biologically relevant parameters in its predictions of cell survival, as it can now account for manipulations of the indirect action for a given oxygenation status, e.g., by administered radical scavengers. Our model is found to accurately predict experimental data available in literature, validating the assumptions made in our approach.
Indirect Action of X-Radiation on Mammalian Cells.